The web site

The Anisotropic Network Model web server at 2015 (ANM 2.0), Eyal E, Lum G, Bahar I. Bioinformatics. pii: btu847, (2015) New version 2.0 (pdf) Abstract (PMID:25568280)

Anisotropic network model: systematic evaluation and a new web interface, Eyal E, Yang LW, Bahar I. Bioinformatics. 22, 2619-2627, (2006) Original Paper (pdf) Abstract (PMID:16928735)

The model

Dynamics of proteins predicted by molecular dynamics simulations and analytical approaches: application to alpha-amylase inhibitor , Doruker, P, Atilgan, AR & Bahar, I, Proteins, 15, 512-524, (2000). Full Paper (pdf) Abstract (PMID:10861943)

Anisotropy of fluctuation dynamics of proteins with an elastic network model , Atilgan, AR, Durrell, SR, Jernigan, RL, Demirel, MC, Keskin, O. & Bahar, I. Biophys. J. 80, 505-515, (2001). Full Paper (pdf) Abstract (PMID:11159421)

Related simple EN models

Tirion, M. (1996) Large amplitude elastic motions in proteins from a single-parameter, atomic analysis, Phys Rev Lett, 77, 1905-1908. (PMID:11159421)

Hinsen, K. (1998) Analysis of domain motions by approximate normal mode calculations, Proteins, 33, 417-429. (PMID:11159421)

Tama, F., Gadea, F., Marques, O. and Sanejouand, Y. (2000) Building-block approach for determining low-frequency normal modes of macromolecules., Proteins, 41, 1-7. (PMID:11159421)

Li, G. and Cui, Q. (2002) A coarse-grained normal mode approach for macromolecules: an efficient implementation and application to Ca(2+)-ATPase., Biophys J, 83, 2457-2474. (PMID:11159421)

Selected biological applications of ANM and related simple EN models

Rader, A., Anderson, G., Isin, B., Khorana, H., Bahar, I. and Klein-Seetharaman, J. (2004) Identification of core amino acids stabilizing rhodopsin, Proc Natl Acad Sci USA, 101, 7246-7251.

Rader, A., Viad, D. and Bahar, I. (2005) Maturation dynamics of bacteriophage HK97 Capsid, Structure, 13, 413-421.

Tama, F. and Brooks, C. (2005) Diversity and identity of mechanical properties of icosahedral viral capsids studied with elastic network normal mode analysis., J Mol Biol, 345, 299-314.

Tama, F., Valle, M., Frank, J. and Brooks, C. (2003) Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy, Proc Natl Acad Sci USA, 100, 9319-9323.

Valadie, H., Lacapcre, J., Sanejouand, Y. and Etchebest, C. (2003) Dynamical properties of the MscL of Escherichia coli: a normal mode analysis, J Mol Biol, 332, 657-674.

Hung, A., Tai, K. and Sansom, M. (2005) Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions, Biophys J, 88, 3321-3333.

Isin, B., Doruker, P. and Bahar, I. (2002) Functional motions of influenza virus hemagglutinin: a structure-based analytical approach, Biophys J, 82, 569-581.

Delarue, M., & Sanejouand, Y.H. (2002): "Simplified normal modes analysis of conformational transitions in DNA-dependant polymerases: the Elastic Network Model", J. Mol. Biol. vol.320, p1011-1024.

Shrivastava, I. and Bahar, I. (2006) Common mechanism of pore opening shared by five different potassium channels, Biophys J, 90, 3929-3240.

Keskin, O., Durell, S., Bahar, I., Jernigan, R. and Covell, D. (2002) Relating mo-lecular flexibility to function: A case study of tubulin, Biophys J, 83, 663-680.

Chunyan, X., Tobi, D. and Bahar, I. (2003) Computational prediction of allosteric structural changes by a simple mechanical model: application to hemoglobin T

Temiz, N. and Bahar, I. (2002) Inhibitor binding alters the directions of domain motions in HIV-1 reverse transcriptase, Proteins, 49, 61-70.